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Xylocaine (Ointment)
Manufactured by: AstraZeneca
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Xylocaine is a local anesthetic used to produce numbness in the mouth and throat. Xylocaine is used to treat sore throat, mouth or esophageal sores, or swelling inside the mouth. Xylocaine may also be used to prevent gagging during dental procedures. Xylocaine MAY REDUCE your ability to swallow. Do not eat for at least 1 hour after using Xylocaine. Xylocaine MAY CAUSE NUMBNESS of the tongue or mouth lining. Do not eat or chew gum while your mouth feels numb. Also be careful not to bite your tongue or the inside of your mouth after using this medicine. Xylocaine IS EXCRETED IN BREAST MILK. IF YOU ARE OR WILL BE BREAST-FEEDING while you are using Xylocaine, check with your doctor or pharmacist to discuss the risks to your baby.
Xylocaine is an amide-type local anaesthetic and is currently the most widely used local anaesthetic in the world. Lidocaine stabilizes the neuronal membrane by inhibiting the ionic fluxes required for the initiation and conduction of impulses, thereby effecting local anesthetic action. Local anesthetics of the amide type are thought to act within the sodium channels of the nerve membrane. Anesthesia is achieved within 5 minutes, depending on the area of application. Duration of anesthesia is approximately 20 to 30 minutes. Lidocaine is ineffective when applied to intact skin. Lidocaine, like other local anesthetics, may also have effects on excitable membranes in the brain and myocardium. If excessive amounts of drug reach systemic circulation rapidly, symptoms and signs of toxicity will appear, emanating from the central nervous and cardiovascular systems. Lidocaine should be used with caution in patients with sepsis and/or traumatized mucosa at the area of application, since under such conditions there is the potential for rapid systemic absorption. When used for endotracheal tube lubrication, care should be taken to avoid introduction of the jelly into the lumen of the tube. If allowed into the inner lumen, the jelly may dry on the inner surface leaving a residue which tends to clump with flexion, narrowing the lumen. There have been rare reports in which this residue has caused the lumen to occlude. Similarly, do not use the jelly to lubricate the endotracheal stylettes. Lidocaine is excreted in the breast milk, but in such small quantities that there is generally no risk of affecting the infant at therapeutic dose levels.
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